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ea0029p704 | Diabetes | ICEECE2012

Pathway Integration of Pro-Inflammatory Cytokines, 12-Lipoxygenase and NADPH Oxidase in Beta Cell Dysfunction; Protection by Novel Selective 12-Lipoxygenase Inhibitors.

Taylor-Fishwick D. , Weaver J. , Ganesha B. , Holman T. , Jadhav A. , Maloney D. , Nadler J. , Simeonov A.

In this study we explore and integrate a pathway for loss of functional beta cell mass in diabetes. Inflammatory cytokines induce human islet dysfunction, elevate expression of 12-lipoxygenase, increase cellular reactive species and induce NADPH oxidase. These pathways are elevated in islets from diabetic donors.NADPH oxidase-1 (NOX-1) is significantly induced in either human donor islets, primary mouse islets or homogeneous beta cell lines following sti...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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